Dengue fever is on the move. Propelled by climate change, this serious mosquito-borne viral infection is spreading to new territories and has come to menace over half the planet’s population. Attempts are underway to curb dengue with vaccines and biological controls, but whether effective measures will keep on working is unclear. This project will use a tool called deep mutational scanning to study how dengue and other mosquito-borne viruses might evolve to adapt to new environments and novel control efforts. What the researchers learn will help us predict risk from mosquito-borne infections and evaluate whether attempts at control will be sustainable.
Participants
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Chantal Vogels
Assistant Professor of Epidemiology (Microbial Diseases)
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Paul Turner
Rachel Carson Professor of Ecology and Evolutionary Biology
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Maudry Laurent-Rolle
Assistant Professor for the Yale School of Medecine
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Carolina Lucas
Assistant Professor for the Yale School of Medecine
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Nathan Grubaugh
Associate Professor of Epidemiology (Microbial Diseases)
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James Weger-Lucarelli
Research Assistant Professor; Department of Biomedical Sciences & Pathobiology; Virginia-Maryland College of Veterinary Medicine
